Methods of Preparation and Evaluation of the Biological Activity of α-Ketoamides

3 I NTR ODUCTI ON Ket oamides are c ompounds of high biologic al and pharmac eut ic al int erest due t o various biologic al ac t ivit ies, suc h as ant iviral, ant it umor, ant i-inflammat ory, ant agonist , inhibit or, and so on. The ket oamide st ruc t ure is very reac t ive and c an be spec ific ally func t ionalized t o be able t o obt ain int ermediat es of different reac t ions or produc t s. The pec uliarit y of t his mot if has at t rac t ed many c hemist s w ho have st art ed synt hesize ket oamide c ompounds and analyze t heir ac t ivit y in vivo sinc e 90's , and t he int erest st ill grows t oday and various synt hesis prot oc ols are available. The synt hesis of a c ompound- drug requires long proc edures for it t o be approved and t o improve or t ry t o reduc e t imes, effic ient , ec ologic al met hods are given t hat give spec ific produc t s t o avoid off- t arget int erac t ions and obt ain good result s in pre-st udies. c linic ians. The work aims are showing different met hods t o produc e ket o amides and t o illust rat ing some of t heir major ac t ivit ies t o highlight t he power of t his resourc e, t he versat ilit y and t he import anc e of st udying t hese molec ules t o obt ain valid pharmac eut ic al t arget s